5. She died after giving birth to her 9th child aged just 39
Lucrezia’s later life was full of grief. By 1518, both her parents, her firstborn son with Giovanni, all of her siblings, and Francesco were all dead. Aged 39, her health was very poor, and she was wracked with sadness. She fell pregnant again, and her health worsened. On June 15, 1519, Lucrezia gave birth prematurely to a little girl, who died within hours. 9 days later, Lucrezia herself passed away. Duke Alfonso was so inconsolable that he passed out at her funeral. He lived for another 15 years and was buried alongside his beloved wife in 1534.